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05 April 2024, 14:51

Formulation factors affecting foam properties during vacuum foam-drying 

This article investigates how vacuum foam-drying of a bioactive protein is influenced by different formulation parameters by scrutinizing the foam structure, physical properties of the foam (protein surface coverage and matrix stability), and the activity of the protein. Formulation parameters differed on matrix formers and the presence of different surface-active competitors. The results showed that the activity of the protein was preserved after vacuum foam-drying and rehydration. Moreover, the thickness of the dry, solid foam was estimated to be 20–50 µm. Interestingly, the choice of matrix former, and to some extent the presence of a surface-active competitor, greatly impacted the foam formation, the protein surface coverage, and the matrix stability. 

Authors: Daniel Tristan Osanlóo, Denny Mahlin, Björn Bergenståhl, Simon Bjerregard & Anna Millqvist-Fureby.

Link to the article: International Journal of Pharmaceutics, Volume 652, 2024, 123803 

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