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Risk assessment of screening of non-intentionally added substances (NIAS)

Name of service (page headline, shown in promos – maximum of 70 characters incl. spaces): Risk assessment of “NIAS-screening” Lead (include SEO-words and the main benefits for your target groups. Stick to one paragraph, maximum 2-3 sentences):

Product safety is an issue of very high concern for all kinds of materials and products. One of RISE´s core activities in this area is analyses of packaging and materials intended for food contact (FCM).

Purpose/Benefit:

Non-intentionally added substances (NIAS) are chemicals that may be present in food contact materials (FCMs) without being intentionally added. NIAS can be divided into three groups: impurities, reaction products and breakdown products. These substances may migrate into food and pose a safety risk to consumers.

To mitigate the risk, NIAS testing and evaluation are needed which together with other analyses like specific and overall migration testing helps ensure that materials are safe.

Method (what/which methods are used to perform the service):

We offer screening of volatile and semi-volatile compounds with gas chromatography-mass spectrometry analysis [Screening for migration of substances from food contact material at 10 ppb level | RISE]. 

Our toxicologists identify the presence of any hazardous substances among the identified compounds based on literature surveys and/or internationally recognised scientific principles on risk assessment (e.g. the TTC approach / Cramer classification). This data combined with exposure assessment from migration studies or literature data is utilized by our regulatory and toxicology experts to make a final risk assessment. 

GC-MS screening is the current “state of the art” technique for NIAS screening. It covers a broad range of possible NIAS. However, there is no standardized and approved method for NIAS testing, and all potential substances may not be tested with only one method. If wanted, we can also support you in setting up a test program and suggest other suitable complementing methods to fully evaluate your food contact material or article [Product safety analyses of food contact materials | RISE].

Delivery (what does the client get after performed service – e.g. a report, certificate etc.):

We provide a risk assessment report which is based on the 10 ppb-screening report. 

Delivery time:

2-4 weeks depending on sample preparation.

Area:
Packaging
Chemical processes and products
Chemical and biological analysis
Product safety
Contact person (Enter one name per field. Activated personal contact pages will appear automatically):
Hans Steijer
Charlotte Nilsson, Toxikolog
Vial Well Plate
Field measurements: No Price type: 1 Division: Division Bioeconomy Preparation: No preparation required Link to order form: Kontakta oss Certification and marking: Not applicable Type of service: Testing / Analysis / Evaluation Instrument: Not applicable General area: Not applicable Order information: För uppdrag och konsultation, kontakta någon av våra experter! Klicka på knappen nedan för att skicka e-post till FCM.productsafety@ri.se Divison (OLD): Division Bioeconomy Delivery level: Not applicable
hans.steijer@ri.se
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9. Industry, innovation and infrastructure
12. Responsible consumption and production
Purpose - Header: Purpose Metod - Header: Method Delivery - Header: Deliveries More information - Header: More information
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Packaging Sekundär områdes navigation:
Health and life science
Food
Tjänstetyp tagg: Konsultuppdrag

Listing of substance in BfR for use in Food Contact Materials

Listing of substance in BfR for FCM
Sandwich on red paper napkin

The rules for Food Contact Materials (FCM) are based on what evaluated substances are used. With RISE's various competencies in material development, chemical analyses, toxicological risk assessment and knowledge of the regulations, we can offer assistance in getting new substances listed in BfR.

The rules for food contact materials are based on what risk assessed substances are used. The German Federal Institute for Risk Assessment (BfR) publishes recommendations for how paper and other materials can be manufactured and tested to be suitable for food contact. With RISE's various competencies in material development, chemical analyses, toxicological risk assessment and knowledge of the regulations, we can offer assistance in getting new substances listed in these recommendations, or supplementing already listed substances with extended areas of use.

Objective

We offer assistance in preparing an application to BfR to have a substance listed in one of the recommendations for food contact materials. The workflow follows the BfR guideline for the safety assessment of substances for the manufacture of food contact materials and articles.

Method

The assignment starts with an assessment of the idea, including the identification of any similar and already listed substances. An initial health risk assessment of the substance based on already available data is developed. An extended work plan can then be developed.

An application is based on two elements: How much of the substance can be transferred to the food and a toxicological evaluation.

Evaluation of the transfer of the substance to food in the intended use is measured or calculated. Potential impurities in the substance are also identified through analyses.

Based on the level of transfer to the food, a toxicological assessment is performed. This includes at least an assessment of genotoxicity. In addition, the project may include uptake, distribution, metabolism, and excretion, oral sub-chronic toxicity, oral chronic toxicity/carcinogenicity, and reproductive and developmental toxicity.

The results are presented in the form of a report.

The project can be organised in different steps that build on each other. Please contact us to discuss an approach.

 

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Division (OLD): Division Bioeconomy Division: Division Bioeconomy Food

DynoMag – a magnetic measuring system for many applications

DynoMag

To be able to reliably characterize nanostructured materials, including magnetic nanoparticles (MNP), is crucial for standardizing MNP systems and the application of specific analysis methods. The DynoMag system, developed at the RISE Magnetic Sensor Systems Lab in Gothenburg, offers a reliable and integrated magnetic measurement system for biodetection using MNPs and rheological measurements.

Highly interesting work and research are currently underway in defining and standardizing various nanostructures. To enable effective research, reliable and standardized measuring instruments and methods are required. At the RISE Magnetic Sensor Systems Lab, we have successfully developed and standardized measurement instruments and methodology for dynamic magnetic measurement and analysis, which are part of standardized measurement systems for MNPs.

Christer Johansson, senior expert at the Sensor Systems unit at RISE, explains that in dynamic magnetic measurements, an alternating (AC) magnetic field with a specific frequency and amplitude is used on the sample. The resulting dynamic magnetic response, also called AC-susceptometry (ACS), is measured contactless through coils and sensitive magnetic measurement technology.

“The DynoMag system, developed and manufactured at the RISE Magnetic Sensor Systems Lab in Gothenburg, has been central in over 160 scientific articles, particularly in the magnetic analysis of MNP systems. The goal has always been to create a sensitive and user-friendly measurement system with integrated electronics and software, along with associated magnetic models for accurate analysis of measurement data”, says Christer.

The development of DynoMag and other similar ACS systems has been conducted in both internal projects and several EU projects, as well as nationally funded projects. Through the EU projects NanoMag and MagNaStand, the DynoMag system and the measurement methodology have been further developed, resulting in an approved ISO standard for ACS measurement methodology for MNPs. 

“By sweeping the frequency and measuring the sample response, the DynoMag system, with its magnetic models, can identify magnetic relaxations and determine the particle size distribution for MNP systems in colloidal solution”, Christer continues.

Another application is monitoring the stability of MNP systems over time under external influences, or as a quality assurance method in the manufacturing of MNP systems to maintain optimal properties or develop new applications. The ACS response in the frequency domain varies depending on the MNP configuration and the presence of particle aggregates.

Through ACS measurement technology and optimal MNP systems, rheological properties can be determined for different substances, from simple Newtonian fluids, like water and glycerol solutions, to complex non-Newtonian substances like gelatin and Xanthan solutions used in the food industry. In a successful project funded by Formas, RISE, together with Chalmers University of Technology, utilized ACS measurement methodology and optimal MNP systems to measure viscoelastic properties in food research. 

The DynoMag ACS system also enables sensitive detection of biological markers by measuring and analyzing the response from functionalized MNP systems. A successful project in collaboration with Chalmers University of Technology, Karolinska Institute, Uppsala University, and Stockholm University, funded by SSF, resulted in an integrated measurement system for influenza. 

“In summary, the DynoMag system is a key component for the characterization of magnetic nanostructures, rheological studies, and biomedical research, with its applications spanning across various disciplines and fields”, Christer concludes.

The DynoMag System

The DynoMag system is a portable easy to use AC susceptometer for measuring the dynamic magnetic properties of liquids, powders and solids at room temperature. The excitation frequency range is from 1 Hz up to 500 kHz with a resolution in volume susceptibility 1·10-5 (SI units) at 1 kHz and a excitation field amplitude of 0.5 mT.

Typical application areas:

  • AC susceptibility measurements of solids, powders and liquids
  • Dynamic magnetic analysis in the field of magnetic nanoparticles (MNPs)
  • Determine the size distribution of magnetic nanoparticles using an algorithm included in the software of the DynoMag (including both Brownian and Néel relaxation)
  • Study stability and possible particle clustering during for instance bio-functionalizing of MNPs
  • Follow the binding reactions of biomolecules to MNPs
  • Measurement of magnetic properties in geophysics

Helena Wiberg

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Jakob Blomgren

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Metrology Sekundär områdes navigation:
Sensors and sensor systems
Health and life science
Food
Composites
Chemical and biological analysis

Bioeconomy Innovation Platform

Innovationsplattform Bioekonomi
Innovation platform Bioeconomy

The Bioeconomy Innovation Platform project is run by RISE Processum and builds on a model developed to initiate, conduct and support needs-driven research and innovation in collaboration with industry, academia and society.

Projectowner
Active
Bioeconomy Biorefinery
Region Västernorrland
2027-01-31
15 576 841 SEK
Division: Division Bioeconomy

Resource efficient use of blue and green natural resources such as water and forests, as well as residual streams from forests, agriculture and the food industry, is crucial to achieving the goal of climate neutrality by 2050. Middle Norrland has a unique opportunity to contribute to the processing of industrial residual streams into important resilient value chains in food, feed, biochemicals, biomaterials and biofuels.

With the project Innovation Platform Bioeconomy, the goal is to contribute to increased growth in the region's bioeconomy companies and create better conditions for more bioeconomy companies to be established in the region.

Small and medium sized enterprises important for increasing innovation capacity

Small and medium sized enterprises (SME) are an important part of Sweden's business and development, but rarely have the opportunity to conduct their own research and development activities. The project aims to support SME for increased growth and competitiveness by increasing innovation capacity and making infrastructure, experts, financing and networks available. By inviting SME to take part in the innovation platform's open working model, companies can receive support with research and development as well as business models and commercialisation.

Yvonne M Nordin

Senior Project Manager
+46 10 516 67 65 Read more about Yvonne M
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9. Industry, innovation and infrastructure
Project end date: Biobased circular processes Sekundär områdes navigation:
Biobased circular processes
Food
Biobased materials
Service innovation

The mussel puzzle

The mussel puzzle
Mussel puzzle

Blue mussels are a nutritious and low-impact source of food, independent of global supply chains of feed and advanced technology. The mussel puzzle project will address knowledge gaps regarding how farming techniques, strategies and location affects the environmental impact of upscaled production.

Project manager/coordinator
Active
Food Maritime
3 years
2 999 000 SEK
Division: Division Bioeconomy

Interest is growing to significantly increase the use of mussels as food or food ingredient. Considering the global expansion potential, surprisingly little is known about the importance of specific farming techniques, strategies and location chosen for environmental impact. In the mussel puzzle project, it will be assessed how increased production is possible while minimizing the environmental footprint. 

Three years of production data will be collected from key producers in the North Atlantic, to demonstrate reduction opportunities for each region and technology. In addition, the expansion potential in these regions will be modelled, together with environmental effects of a more large-scale production, to identify potential environmental trade-offs and ways to minimize these. In this way, the project intends to facilitate a large-scale shift, from food with larger environmental footprint and lower nutritional content, to mussels.

Are you a mussel farmer or know someone who might be interested in participating? Get in touch!

Friederike Ziegler

Forskare
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12. Responsible consumption and production
14. Life below water
Project end date: Food Sekundär områdes navigation: Circular transition

Swedish Fish Industry Association backs up claims with evidence

Salmon

The Swedish Fish Industry Association needed more meat on its bones to explain the state of knowledge and answer burning questions. They found the answer in independent expertise. - All industries benefit from moving from opinion-based to fact-based discussions, says chairman Krishan Kent. 

Krishan Kent

Is Swedish demand for Norwegian salmon linked to the move from small-scale to large-scale fishing in the Baltic Sea, where the catch is used as feed?

"Salmon is the most consumed fish in Sweden, so it is very important for us to understand how we can eat it with a clear conscience. If there are problems, we need to understand them so that we can act together with the relevant stakeholders," says Krishan Kent, Chairman of the Swedish Fish Industry Association.  

Independent review of research 

The industry organisation represents more than 165 companies from sea to table, with a combined turnover of almost SEK 18 billion and 5,000 employees. The Swedish Fish Industry Association works for a sustainable "blue" food chain. This includes ensuring that there are functioning regulations, guidelines and trade policy instruments that make the supply of raw materials to Swedish companies qualitatively and quantitatively secure. Answering questions from the industry is also an important part of the work.  

"I believe that all industries would benefit from moving from discussions based on opinions to a common platform based on facts. When I look at our industry, I feel that the fact base on seafood is generally quite weak and the dialogue is fragmented with many stakeholders in different channels," says Krishan Kent.

"In this case, there had been discussions about whether Norwegian salmon farming was having a negative impact on the ecosystem in the Baltic Sea, and we wanted to understand more about it."

I think all industries would benefit from moving from discussions based on opinions to a common platform of facts

Taking ownership of the problem

RISE has twice compiled and analysed available data, industry data and public reports. This has resulted in reports that the Swedish Fish Industry Association now uses as a knowledge base. These include reports on the nutritional content, undesirable substances and climate footprint of farmed salmon, and on whether Swedish consumption of farmed salmon is driving Swedish industrial fishing in the Baltic Sea.

"We chose RISE because we believe they are the strongest independent actor linking industry and research," says Krishan Kent.

Friederike Ziegler, researcher and project manager for sustainable seafood at RISE:

"Seafood is quite complex, involving many different production systems and many actors with different perspectives. It can be difficult to navigate. The Swedish Fish Industry Association cannot be familiar with all the technical details. That is why they wanted an independent review of what the research says about the claims being made."

"I think it's impressive that a trade organisation like the Swedish Seafood Federation wants to find out what the situation is without preconditions and put the cards on the table."

Krishan Kent:

"We choose to be transparent in order to take responsibility for any problems, so that the issues come to us rather than floating around on social media. We want to show that we are following, seeing and taking the issue of farmed salmon seriously."

"The latest report shows that there is a very small link between the consumption of Norwegian salmon and the industrial fishing of herring in the Baltic Sea, but it is still the case that there are things we need to work on to ensure a sustainable Swedish market in the long term."

Want to be more proactive

In the debate about fishing and seafood, new issues are constantly emerging. The Swedish Fish Industry Association has therefore asked RISE to help it plan which questions the organisation should answer in the future. The idea is to move away from being reactive to things that flare up in the media, to thinking about what knowledge is needed to provide clear and robust information, thereby creating the factual platform that is currently lacking.

"At our Seafood Forums, where we meet with stakeholders, we highlight the big issues and the bubbles that have not yet burst. We want to develop this approach further. Our members and stakeholders should be confident that we as an industry association have a factual basis and credibility, not just opinions," says Krishan Kent. 

WHAT IS SEAFOOD?  

Seafood is a collective term for fish, shellfish and seaweed. Seafood feeds up to 800 million people worldwide. It is estimated that seafood consumption by edible weight will increase by 80 per cent by 2050 (source). Sustainable fishing and farming is becoming increasingly important to protect the marine environment and ensure the availability of seafood for future generations.

Friederike Ziegler

Forskare
+46 70 420 56 09 Read more about Friederike
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Food Sekundär områdes navigation:
Circular transition
Chemical and biological analysis

Sustainable future meals - 9outof10

9outof10 innovation platform
Dietary shift for a diet within planetary boundaries in Sweden

Sustainable, healthy food, available to everyone that tastes good! Together we create a food system within the planetary boundaries.

Koordinator
Active
Circular transition Climate adaptation Food
Not applicable
48 månader
7 499 139 SEK
Division: Division Bioeconomy

Mission: At 2040,  9 out of 10 meals consumed in Sweden are within the planetary bounderies. 

Striving to: 

Increase availability of nutritious and sustainably produced food through infrastructure for financing the sustainable transition of agriculture.

Increase demand for nutritious and sustainably produced food through innovative incentive mechanisms.

How do we do this?

We create neutral meeting places were we gather actors with the capacity to identify specific needs for innovation and development. Based on the needs, we initiate projects and collaborations that can contribute to getting closer to acheiving the mission. Examples of projects are: 

  • Universal Basic Nutrient Income (UBNI)- meal concept, nutritious healthy food for everyone.
  • Support systems for legume production. Policylab.
  • Optimized meals - for companies to be able to evaluate their products both on bioavailability of iron and a good climate footprint.
  • Climate scale climate key figures for municipalities' purchases.

Please contact us if you are interested in knowing more about our work and how to be involved in the process!

Hanna E Svensson

Projektledare
+46 10 516 66 44 Read more about Hanna E
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Cecilia Åkerblom

Projektledare
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2. Zero hunger
12. Responsible consumption and production
Projekt logo: Logga Project end date: Food Sekundär områdes navigation:
Circular transition
Agriculture
Service innovation

Preliminary study on circular synergies between land, forest and sea u

Cirkular synergies
A group of fish swims in a turqouise sea

How can we increase circularity and create the highest possible value from industrial residual flows? Within a feasibility study, the aim is to identify focus areas for industrial symbiosis and potential partners in the forest industry and the fish farming industry across the Sweden-Norway border.

Project owners
Completed
Bioeconomy
Four months
33 440 EUR
Division: Division Bioeconomy

Whether materials, energy or chemicals, virtually all production gives rise to some form of residual flows that need to be managed. Higher demands on circularity mean that more producers need to see the value and take care of residual flows in the best possible way. The project brings together industry, research institutes, and stakeholders in agriculture, forestry and marine management to explore opportunities to integrate and optimize our natural resources for a sustainable future.

The aim of this feasibility study is to

  • Explore opportunities to collaborate in land, forest and marine industrial activities with a focus on bioresource circularity within the blue-green cycle. 
  • Identify and initiate discussions with interested parties on both sides of the border in the local community, industry and academia, where access to residual streams and/or technology exists to further close the cycles and contribute to a lower environmental footprint. 
  • Investigate conditions for cooperation and knowledge transfer with upper secondary school and vocational programs in bioeconomy 

Final report 

The feasibility study has provided a fruitful basis for understanding the residual flows and needs on both sides of the border in the blue-green cycle. There has been great interest among various stakeholders, from the agricultural side, the forestry industry, the aquaculture industry, as well as in teaching and academic institutions and green industry sites, which work with industrial symbiosis. The desire to collaborate further to learn from each other and find forms of cooperation between industrial sites is high, which shows that the circular is a highly topical subject where the endeavour to be part of the blue-green transition is strong in the regions. The project has illustrated that there is a clear synergistic added value of working across the border regions on nutrient flows and carbon flows, but also highlighted difficulties regarding differences in national / EU regulations for nutrient recycling of fish sludge, logistics for residual stream management and getting techno-economically sustainable value chains.

Eleonora Borén

Innovations- och processledare
+46 10 516 67 96 Read more about Eleonora
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Yvonne M Nordin

Senior Project Manager
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2. Zero hunger
4. Quality education
9. Industry, innovation and infrastructure
12. Responsible consumption and production
14. Life below water
17. Partnerships for the goals
Project end date: Circular transition Sekundär områdes navigation:
Maritime
Pulp and paper
Food
Agriculture

Research and innovation against antibiotic resistance, in line with the One Health approach

Antimicrobial resistance

Antimicrobial resistance, AMR, is a growing public health problem both in Sweden and worldwide. We all need to help protect antibiotics. And it is urgent. RISE collaborates with companies, academia and the public sector, and we offer a variety of services linked to the work against antimicrobial resistance.

Antibiotics are one of our most important medicines. Antibiotic resistance occurs when bacteria develop resistance to antibiotics. The antibiotics become ineffective and the infections caused by the resistant bacteria become difficult to treat. For antibiotics to remain effective and for us to stop resistant bacteria, society as a whole must contribute. Everyone needs to be aware of the problem and act in a way that reduces the spread of infection and the need for antibiotics. We also have to secure access to existing antibiotics and use them wisely.  Antibiotic resistance is part of the broader concept of antimicrobial resistance, which also includes the resistance of viruses, parasites and fungi to different types of antimicrobials.

The One Health perspective means that the use of antibiotics and other antimicrobials in humans, animals and nature affects the overall increase of resistance in society. Therefore, action is needed in all areas.

How RISE works to fight antibiotic resistance

RISE works against antibiotic resistance by participating in research and innovation that helps to:

  • prevent the emergence of infections
  • counteract the spread of infection
  • treat infections
  • improve diagnostics and surveillance
  • contribute to the wise use of antibiotics.

We work broadly from a One Health perspective and we offer expertise in several areas.

A selection of areas in which RISE is working against antibiotic resistance:

Antibiotics, vaccines & new antimicrobials

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The societal perspective

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Protective equipment, medical devices & healthcare

+

Hygiene & cleaning

+

Food production, food safety & animal husbandry

+

Air & water treatment

+

Antimicrobial materials, surfaces & coatings

+

Microbiological evaluation & analysis

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Want to know how RISE can help you? Do you have other questions? Contact us by filling in the form on this page.

Nadine Kraupner

Forskare
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Ulla Elofsson

Assoc. Professor
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Division: Division Materials and Industry Område:
Infection control
Preventive healthcare
Infection control Sekundär områdes navigation:
Water
Medtech
Food
Composites