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Biotransformation of brewers´ spent grain

FUNBREW
BSG spaghetti

The aim of FUNBREW is to establish bioprocessing technologies for the synthesis in situ of functional compounds in BSG.

Participant and WP leader
Completed
Food
36 m
Division: Division Bioeconomy

Brewer´s spent grain (BSG) is a byproduct of beer manufacturing and is rich in fibers and protein. Today it is used as animal feed or discarded. The aim of FUNBREW is to establish bioprocessing technologies (fermentation and enzyme treatment) for the synthesis in situ of functional compounds in BSG, such as exopolysaccharides and antioxidants. Bioprocessing results in improved structure as well as enhanced bioavailability of BSG constituents. BSG will be used as an ingredient in pasta, bread and breakfast cereals.

This transnational project is part of the ERA-Net SUSFOOD2 with funding provided by national/ regional sources FORMAS and co-funding by the European Union´s Horizon 2020 research and innovation program.

Annika Krona

Senior Scientist
+46 10 516 66 38 Read more about Annika
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2. Zero hunger
3. Good health and well-being
9. Industry, innovation and infrastructure
12. Responsible consumption and production
University of Helsinki University of Bari Free University of Bozen-Bolzano
Projekt logo: FUNBREW Funders without URL:
FORMAS
Horizon 2020 ERA-NET SUSFOOD2
Project end date: Food Sekundär områdes navigation:
Circular transition
Biotechnology
Biobased circular processes

ISO 10993-23 Skin Irritation - in vitro

Name of service (page headline, shown in promos – maximum of 70 characters incl. spaces): ISO 10993-23 Skin Irritation - in vitro Lead (include SEO-words and the main benefits for your target groups. Stick to one paragraph, maximum 2-3 sentences):

Irritation testing is a critical component of the biological evaluation of medical devices and a necessary step to meet the requirements of the Medical Device Regulation (MDR). RISE conducts irritation tests according to ISO 10993-23 and adheres to Good Laboratory Practice (GLP).

Purpose/Benefit:

Conducting irritation testing is crucial to ensuring that your medical device is safe for use. These tests help identify whether the product may cause irritation when it comes into contact with the skin.

By performing irritation testing, potential issues can be detected and addressed early in the development process, reducing the risk of adverse reactions for users. This is essential not only to protect patient health and safety but also to comply with regulatory requirements under the Medical Device Regulation (MDR) and international standards such as ISO 10993-23.

Furthermore, irritation testing helps build trust among users and healthcare professionals by demonstrating that your product has undergone rigorous safety evaluations. This not only prevents costly recalls and legal challenges but also ensures that your products are reliable and effective.

Method (what/which methods are used to perform the service):

Our skin irritation tests are based on a model consisting of human epidermal keratinocytes. These have been cultured to form a differentiated model of the human skin layer, which is comparable to the in vivo skin structure.

We perform skin irritation testing according to ISO 10993–23. The product extraction is conducted according to ISO 10993-12. We also conduct skin irritation tests according to OECD Test Guideline 439, where the skin model is directly exposed to a test chemical, without prior extraction.

We follow GLP

We adhere to Good Laboratory Practice (GLP), which ensures that the irritation tests are conducted in a scientifically valid and regulatory-compliant manner.

Delivery (what does the client get after performed service – e.g. a report, certificate etc.):

After completing the irritation test according to ISO 10993-23, you will receive a detailed test report in English. The report includes data showing the skin's reaction after exposure to the test material.

Area: Medical devices Contact person (Enter one name per field. Activated personal contact pages will appear automatically): Karin Nydahl, Laboratorieingenjör
MDR, medical,
Field measurements: No Price type: 1 Division: Division Materials and Industry Preparation: No preparation required Standards:

ISO 10993–23

ISO 10993-12

Certification and marking: Not applicable Type of service: Testing / Analysis / Evaluation Instrument: Not applicable General area: Not applicable Delivery level: Non-accredited
karin.nydahl@ri.se,
/en/node/9710
More information:

At RISE, we are pleased to offer testing services for medical devices according to both ISO 10993-5 and ISO 10993-23.

We also provide services to ensure that your products can be cleaned, disinfected, and sterilized safely and effectively according to ISO 17664-1/2 and ISO 17665.

By combining our services under these standards, we can help ensure that your medical devices are both biocompatible, sterile, and suitable for reuse—critical factors for patient safety and the product's success in the market.

Feel free to contact us for more information or to schedule a consultation.

3. Good health and well-being
Purpose - Header: Why conduct irritation tests? Metod - Header: Which methods do we use? Delivery - Header: Delivery
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Medtech Sekundär områdes navigation:
Metrology
Biotechnology
Tjänstetyp tagg: Provning

How AI can revolutionise healthcare

How AI can revolutionise healthcare

In a short period of time, AI has gained a foothold in both business and the public sector. But it is perhaps in medicine and healthcare that AI's ability to interpret large amounts of data will have the most transformative impact – and could save lives.

AI is already being used for tasks such as image analysis, predictive analytics, patient monitoring and automated surgery. But in the near future, AI could also help doctors diagnose serious illnesses more easily and become an important tool for improving mental health care.

Fehmi Ben Abdesslem is a senior researcher in Artificial Intelligence at RISE. He has 20 years' experience as a data science researcher, working with many different types of data to generate new knowledge, particularly using machine learning.

"There are many potential benefits of using AI in medicine and healthcare, such as improving diagnostic accuracy and developing personalised treatment plans. AI can also be used as a tool for early detection of diseases and to improve efficiency in clinical settings," says Fehmi Ben Abdesslem.

Personalised care through AI

The development of AI has opened the door to new ways of conducting research studies. Image recognition, for example, has taken a giant leap forward in the last decade. Thanks to deep learning techniques, computers can now recognise objects with very high accuracy (see fact box).

Another area where AI can become a force for innovation – and perhaps ultimately help save lives – is mental health.

"For example, by allowing AI to sift through large amounts of data, doctors can get important clues about the type of medicine or therapy best suited to a patient, which could lead to a faster recovery. Because AI can be trained on huge amounts of data, we also hope that machine learning can be used to prevent suicide," says Fehmi.

A collaboration between Psykiatri Sydväst, Region Stockholm and RISE is investigating whether AI can improve cognitive behavioural therapy at the individual level. Using data from thousands of patients, AI will help a therapist assess the impact of therapy on the patient, with the aim of making it easier to individualise therapy early in the course of treatment. In addition, the team hopes that AI will be able to identify which patients may need more help after therapy.

Another example is a collaboration between RISE and the Faculty of Brain Sciences at UCL (University College London) in the UK, which used AI to compare the individual effects of different types of psychotropic drugs for bipolar disorder, using data from Sweden, the US, the UK, Taiwan and Hong Kong.

"At the moment, we don't know why one drug works better than another. By building machine learning models, we are investigating whether AI can recommend which drug is best for a person based on their specific condition."

We aim to build long-term relationships and collaborations that can make a difference to people's health and well-being.

We strive for long-term relationships and partnerships that can make a difference to people's health and well-being.

Fighting suicide with AI

In the near future, machine learning will hopefully also become a tool for predicting suicide.

"800,000 people around the world take their own lives every year. What if data on their DNA could give us clues about risk factors and, in the long run, prevent suicide?," says Fehmi Ben Abdesslem.

The American Foundation for Suicide Prevention, Karolinska Institutet, the Department of Genetics at the University of North Carolina and RISE have launched a joint project to create the world's largest collection of data on suicide. The aim is to be able to identify genetic and environmental risk factors for suicide for prevention purposes.

The idea is to let AI sift through a huge amount of data, with instructions to look for all kinds of environmental variables and genetic variants and risks that can be linked to suicide.

"Previous studies have shown that our DNA may play a role in increasing the risk of suicide. Since we take a blood sample from all citizens when they are born in Sweden, we have a unique DNA database that can be used to advance suicide prevention research worldwide," says Fehmi Ben Abdesslem.

Addressing ethical issues

In order to develop a more digitalised, preventive and personalised healthcare system, many factors need to be ensured. There are several ethical challenges, such as how to obtain consent from individuals, how to counteract algorithmic bias, and how best to protect patient privacy.

Access to high-quality data is a crucial piece of the puzzle, but logistics in the form of continuous monitoring and updating of AI systems also need to be in place to scale up the safe use of AI.

Fehmi stresses the need for more use cases and more research. Interdisciplinary collaboration between different parties is crucial for the way forward.

"We are looking for long-term relationships and collaborations that can make a difference to people's health and well-being," says Fehmi Ben Abdesslem.

AI FOR IMAGE ANALYSIS: HOW TO FIND ADRENAL CANCER

The adrenal gland is an important organ to examine for signs of lung cancer and melanoma, for example.

In a pilot project between RISE, Karolinska Institutet and Karolinska University Hospital, a machine learning AI model was used to determine the exact three-dimensional shape and size of adrenal glands in just a few minutes.  

The results of the study showed that in many cases AI can make more accurate measurements than a doctor because it can store and interpret endless amounts of data – and compare it in a completely different way than a human can.

However, Fehmi Ben Abdesslem is quick to point out that AI should be seen as a complement to medical science, not a replacement for a doctor's knowledge.

"A doctor's experience and knowledge is still crucial to making diagnosis, but we can provide decision support tools to help radiologists identify changes in the gland and thus help fight cancer."

How RISE is working with AI in medicine

  • Collaborative research: RISE partners with universities and pharmaceutical companies for collaborative research and clinical trials. 
  • Advanced analytics and AI: RISE is using AI and analytics to accelerate drug discovery and optimise drug design.
  • Biotechnology and nanotechnology: RISE develops innovative drug delivery carriers and improves drug targeting.
  • Regulatory expertise: RISE helps to navigate regulatory requirements and ensure compliance with safety and efficacy standards.
  • Pilot and scale-up facilities: RISE provides facilities for the transition from laboratory experiments to commercial-scale drug production. 
  • Experience in coordinating large international (EU-funded) and national projects. 
  • Application partners with AI expertise.

Fehmi Ben Abdesslem

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Digital health Sekundär områdes navigation:
Artificial intelligence
Data Science
Biotechnology

Cirkulär industriell vattenanvändning med enzym-baserad reningsteknik

Cirkulär industriell vattenanvändning
vatten tapp

Projektet validerar cirkulär prestanda för innovativ och högteknologisk vattenbehandlingsteknik genom att tillämpa internationella standarder för cirkulär ekonomi, miljöteknik och digitala produktpass för att rikta vattencirkularitet.

Projektledare, koordinator, delatagare
Completed
Certifiering Kemiska processer och produkter Medicinteknik Vatten
Ej tillämpbart
1,5 år
1 314 995
Division: Använd ej - Division Samhällsbyggnad

Projektet kommer att använda en innovativ och högteknologisk reningsteknik, Zymatic, för att och validera Cirkulär prestanda på process-/avloppsvatten från en industri. Projektet kommer att tillämpa standarder för Cirkulär Ekonomi för att hjälpa till att identifiera en eller flera vatteninitiativ och sedan utvärdera initiativen för fullskalig kapacitet. När projektet valt ut vilken process/vattenström som ska användas kommer interna och externa piloter genomföras för att validera teknikens prestanda och övervaka dess cirkulära prestation. Slutligen kommer reningstekniken att testas ytterligare på liknande strömmar för att förutsäga återanvändbarheten och överförbarheten av lösningen till andra vattenströmmar.

Vattencirkularitet är viktigt för industrier när det gäller hållbarhet, skydd av ekosystem och för ökad konkurrenskraft. Inom kemisk tillverkning, såsom läkemedels- och medicinteknikindustrin och dess värdekedja, är möjligheten att återanvända avloppsvatten till olika produktionsområden eller stödjande processer av stort intresse. Nya regelverk har ökat intresset för vattenåteranvändning de senaste åren. Ett exempel är EU:s ökade krav på industrier genom vattendirektiven Urban wastewater treatment directive (UWWTD) och Surface-and Groundwater Directive (SGD). Här omfatt nya direktiv principerna om att ”förorenarna ska betala”. Detta ger projektet en möjlighet att kombinera innovativa reningslösningar, nya ISO-standarder med behovet av att hitta nya vatteninitiativ.

Tatiana Nevzorova

Senior forskare
+46 10 516 67 04 Read more about Tatiana
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3.Hälsa och välbefinnande
6.Rent vatten och sanitet
9.Hållbar industri, innovationer och infrastruktur
14.Hav och marina resurser
15.Ekosystem och biologisk mångfald
Project end date: Vatten Sekundär områdes navigation:
Cirkulär omställning
Produktion och tillverkning
Bioteknik
Kemiska processer och produkter

How Swedish startups can run faster – and save the world

Sunrise

What role do Swedish innovation companies play in global change? An important one, according to several studies. RISE's Henrik Bagewitz and Leif Lyckebäck, who have met hundreds of innovative small companies, explain the key factors that increase the chances of success.

At the beginning of the 20th century, Sweden was characterised by its ingenious industries, which gave us solutions that fundamentally changed society. More than a hundred years later, we can still boast of our ingenuity. The World Intellectual Property Organisation (WIPO) ranks Sweden as one of the two most innovative nations in the world. Statistics show that we have the most unicorns - companies worth a billion dollars or more - per capita.

"If Silicon Valley were a city, it would be first and Stockholm second. We have a very vibrant start-up and scale-up scene in Sweden and especially in Stockholm," says Henrik Bagewitz, Head of Marketing at RISE.

Swedish start-ups are developing innovative solutions for energy storage, creating breakthrough medicines and exploring new technologies to feed a growing world population. In short, these are companies with disruptive ideas. Some of these companies have been taken under the wing of the Sting incubator. And Sting, which has been voted the best incubator in the world, has joined forces with RISE.  

"We and RISE share a common 'why'; like us, they want to help innovation succeed and get to market faster. Both Sting and RISE work with heavy technology and deep tech. We also share a very clear focus on sustainability, particularly the planetary aspect of sustainability. We saw that by working with RISE we could strengthen our offering to our Climate Tech companies," says Karin Ruiz, CEO at Sting.

"Difficult to find the right funding tools" 

An important part of the collaboration revolves around so-called soft funding, i.e. public support and grants.  

"The Sting companies are sitting on private funds that we can use when it comes to the next stage of development. Every private krona can be converted into two development crowns with the help of the public support system. This way we can inject more capital into the companies," says Leif Lyckebäck, a business developer at RISE with a special focus on innovative start-up and scale-up companies.

According to Leif Lyckebäck, many companies make the mistake of applying for the wrong type of grant, or submit incomplete applications that do not go all the way.

"There is a lot of public funding and national funding from the Swedish Energy Agency, Vinnova and similar organisations. But it can be difficult to find the right funding instruments for your company. That is why we are available to advise the Sting companies and other companies that want to work with RISE in their development. We can ensure that the application meets the criteria, and where the companies themselves have capacity gaps, we can provide expertise and test and demonstration environments," he says.   

If the companies that have the greatest impact on climate and humanity succeed, we all succeed

Bridging the gap between idea and full commercialisation 

The Sting companies working with RISE are primarily in the climate tech sector, using technology to address climate challenges, reduce greenhouse gas emissions and contribute to the green transition. One example is CelluXtreme, which has developed a new bio-based composite material.

"In addition to providing answers to major societal challenges, this type of company has the potential to create a large share of Sweden's jobs and export earnings. RISE acts as a bridge between the idea and full commercialisation, where we reduce the risk and shorten the time to market. It's all about facilitating the development process," says Henrik Bagewitz.  

Over the past two years, he and Leif Lyckebäck have had meetings with more than 400 companies. This has resulted in almost SEK 400 million in funding for about 100 of the companies. About the same number have used RISE's test and demonstration environments and experts.  

"Many of our companies need to test completely new materials, while others want to take their product from laboratory scale to the next level. Having access to RISE's infrastructure is very valuable," says Karin Ruiz.  

Building infrastructure for small and medium enterprises 

RISE's 130 or so test and demonstration facilities are constantly evolving to meet new needs.  

"We are constantly trying to improve the position of our test and demonstration infrastructure. If we take the battery sector as an example, it is a market that is exploding. In order to be relevant, we need to invest in both people and infrastructure. It would not be possible for each individual player to build up this kind of capability," says Henrik Bagewitz.

Collaboration with incubators such as Sting is crucial for getting close to innovative companies. The aim is to play a central role in the innovation system, bringing together different interests for sustainable transition and increased competitiveness - and to complement incubators that share the vision of saving the world through innovative companies.

"If the companies that have the greatest impact on climate and humanity succeed, we all succeed," says Leif Lyckebäck. 

TECHNOLOGY AS A SOLUTION TO SOCIETAL CHALLENGES 

Impact tech, deep tech, climate tech - what is it?  

Impact tech or impact technology are innovations and technical solutions that contribute to greater sustainability. It can range from increasing access to education and healthcare to improving waste management in a society.

Deep tech is an umbrella term for advanced and complex ways of solving problems. AI and nanotechnology are two examples.  

Climate tech is technology to reduce carbon emissions and the effects of climate change.

Henrik Bagewitz

Chef inom strategisk forskning och affärsutveckling
+46 70 952 89 23 Read more about Henrik
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Leif Lyckebäck

Affärsutvecklare
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Innovation management Sekundär områdes navigation:
Circular transition
Energy and electrification
Biotechnology

ALFAFUELS

ALFAFUELS
ALFAFUELS

The ALFAFUELS project aims to reduce the dependence on fossil fuels in the aviation sector. With a new innovative production technology, the aim is to improve the scale-up potential through microbial production for the conversion of CO₂ into fuel precursors that are scaled up and refined into jet fuel using novel photochemical conversion pathways.

Koordinator
Active
Not applicable
2027-12-31
Division: Division Bioeconomy

The global transition from fossil-based energy sources to renewables is crucial to achieving a low greenhouse gas emission economy while meeting future energy needs in a sustainable and efficient way. The ALFA FUELS project can play an important role in the decarbonization of the aviation sector by offering a new approach to sustainable aviation fuels, Sustainable Aviation Fuels (SAF). 

Within the four-year project, funded through the European Union's Horizon Europe research and innovation programme, a multi-faceted approach will be implemented by capturing and using CO₂, developing cost-effective and sustainable technological solutions at every stage of the process, and exploring integration opportunities with other sectors to overcome the current key challenges hindering the technological maturity and commercialization of SAF. To address high production costs, sustainability issues and technological limitations, ALFAFUELS will develop three technological innovations: microbial production for isoprene, solar-powered photochemistry and biorefinery method. 

RISE is the coordinator and responsible for project monitoring, reporting and management of the project. In the project, RISE will cultivate both cyanobacteria and microalgae to generate cell debris which will be hydrolyzed to generate glucose-rich hydrolysate. The glucose-rich hydrolysate will be used as a substrate for co-production of H2 and starch by microalage. The whole process will be upscaled to TRL 5.RISE will also design and develop a photochemical reactor system to scale up the jet fuel production and conduct tests to see how the process, for the production of aviation fuel, works on a larger scale.

Ylva Bruce

Forsknings- och utvecklingsingenjör
+46 10 722 32 19 Read more about Ylva
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Charilaos Xiros

Senior researcher, co-ordinator of Research Biotech Group
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9. Industry, innovation and infrastructure
13. Climate action
Projekt logo: ALFAFUELS Project end date: Fossil-free fuels Sekundär områdes navigation:
Energy and electrification
Mobility
Biotechnology

Sustainable use of marine resources for high value end products

MaRefine
marine bioresources blue refinery

Ocean resources are limited and should be used wisely.

MAREFINE aims to establish a blue biorefinery in Sweden where underutilized marine side streams are valorised into high value products.

Project leader and coordinator
Active
Bioeconomy Biorefinery Circular transition Climate neutral industry Life Science Life cycle analysis Material transition Textile
Västra Götaland Region
5 years
25 MSEK
Division: Division Materials and Industry

The maritime industry has been identified as a growth sector in EU as well as in Sweden. There are also strategic plans to develop the fisheries and aquaculture sector into more innovative and resource-efficient value chains. Today, the seafood processing in Sweden is generating 26 000 tonnes of residual raw materials where the majority goes to feed, biogas, or destruction. However, there is a large untapped potential to use this renewable marine feedstock for the development of more sustainable products for the growing population.

The technological key that enables what is today considered residual streams or waste to be converted into high value products is the biorefinery. In MAREFINE, we will evaluate the processing potential of residual streams from salmon, herring, ulva (green algae), sugar kelp, diatoms and shrimp. The benefits of a blue biorefinery will be maximized - both from a sustainability and economic perspective - by utilizing the entire biomass and extracting as many valuable components as possible to create high-value end products. In MAREFINE, an experienced team of researchers together with actors along the value chain from side stream generation to end product use, will create a basis for a blue biorefinery. The project will also focus heavily on identifying and removing obstacles and developing a business plan for the establishment of a blue biorefinery.

Markus Andersson Trojer

Forskare
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Jessica Hjerpe Olausson

Enhetschef
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14. Life below water
Project end date: Biobased circular processes Sekundär områdes navigation:
Circular transition
Maritime
Biotechnology
Food

Physical state of drugs precipitated in confined spaces

NANO-DRUGS
Project LSRI RISE

This project aims to explore the physical state of APIs within mesoporous magnesium carbonate (MMC) pores using X-ray beams. The investigations aim to uncover mechanisms driving drug precipitation, providing essential insights into release behavior. These findings have the potential to refine drug delivery systems and optimize therapeutic efficacy.

Koordinator
Completed
Pharmaceuticals
Region Stockholm
3 år
2 140 000 SEK
Division: Division Bioeconomy

In this project Disruptive Pharma, a pioneering pharmaceutical company, partners with RISE to study the physical state of APIs precipitated within the pores of MMC using nano-focused X-ray beams. Synchrotron facilities such as MAX IV (Sweden), ESRF (France) or DLS (UK) offer unique capabilities to explore the structural characteristics of these confined systems. 

By examining mechanisms that drive drug precipitation one can unravel critical insights into drug stability, solubility, and release behaviour which can open a wide range of opportunities for pharmaceutical research and development. 

It is expected that the results of these experiments will increase the potential to refine drug delivery systems, enhance bioavailability, and adjust therapeutic efficacy. The interplay between the synchrotron technology and pharmaceutical science creates opportunities for innovative formulations, ensuring that specific interactions between API and porous matrices are deciphered. 

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Project end date: Drug development Sekundär områdes navigation:
Metrology
Biotechnology
Composites