Contact person
Viktor Kallebäck
Forskare
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Controlled Release
Quantifying the release rate of active substances is crucial for understanding and controlling their function in various applications. RISE offers reliable methods to measure, analyze, and model release in relevant environments.
Purpose
Measuring the release rate of active substances is essential in many application areas, such as pharmaceuticals, agriculture, and food. Release can occur from both small carrier particles and macroscopic products such as textiles, coatings, and gels. By carefully measuring the release rate, we can ensure that active substances are delivered effectively and safely. This is particularly important for optimizing dosage, minimizing side effects, and improving product performance over time.
Method
RISE offers a range of methods for measuring controlled release of active substances. The choice of method depends on the specific properties of the active substance, the surrounding matrix, and the release medium (into which the active substance leaks). Different usage environments (e.g., seawater, soil, or a physiological environment such as wound fluid) can be simulated by selecting the appropriate release medium, and accelerated studies can be conducted using higher temperatures or additives that increase solubility in the release medium.
Instrumentation and Analysis
RISE has expertise in accurately measuring and analyzing the release of active substances using methods based on both gas and liquid chromatography as well as UV-vis spectrophotometry.
Modeling of Release Rate
To predict and optimize release profiles, we use various physical release models based on Fick’s law of diffusion. The models are based on both analytical and numerical solutions that, in addition to diffusion constants and partition coefficients, also consider dynamic processes such as interactions with and degradation of the surrounding matrix. Different product geometries can be adapted, from simple small spherical carrier particles or flat coatings to complex nonwovens with an inherent size distribution of fiber radii. These models can help understand the mechanisms governing release and design systems with desired release properties.
Delivery
RISE strives to deliver customized solutions for measuring controlled release of active substances, tailored to each customer’s unique needs. Deliverables may include reports with analysis results, optimized measurement protocols, and recommendations for further product development. We can also offer ongoing support and advice to ensure that the measured release profiles meet desired requirements and standards.
