Green chemistry - from pilot to commercial production
Many process developers find themselves caught between promising laboratory results and commercial production – scaling up proves too expensive, too uncertain or takes too long. At the same time, requirements regarding environmental impact, safety and economic viability are becoming increasingly demanding, even at the early stages of development.
Without the right expertise, projects risk getting stuck at the pilot stage, incurring unnecessary safety risks or encountering regulatory hurdles late in the process – which can delay launch by several years and result in significant financial losses. At RISE, we therefore build sustainability, safety and regulatory readiness into the development phase from the outset.
Key aspects include the use of environmentally friendly chemicals, materials and technologies, as well as reducing energy consumption. Our aim is to develop customised processes for pilot trials through to commercial production, in line with the principles of green chemistry.
RISE guides process development throughout the entire chain – from renewable raw materials and route design to upscaling, chemical analysis, process safety and digitalisation – in close collaboration with the customer, ensuring that new processes are ready for commercial operation more quickly and safely.
Our service covers support at every stage – from raw material selection and route design to pilot-scale testing (TRL 1–6/8) and commercial handover. The first step is often an initial consultation to assess where your project is in the process.
Would you like to know how we can help take your process development forward? Book a meeting and we’ll go through your requirements.
Renewable raw materials and substitution
Substitution of reagents and solvents by greener alternatives and utilization of renewable feedstocks can have a huge impact on the overall environmental footprint. Thus, we focus on the production of green chemicals and renewable fuels from agricultural byproducts or side streams of the forestry industry. We also recognise various fractions of industrial and household waste, such as plastic, as well as CO2 as valuable sources of carbon in the circular economy.
Route design
Synthetic route design enhanced by modern digital tools provides an opportunity to device an efficient, economical, and novel manufacturing strategy for your target compound. Moreover, this enables finding solutions which adhere with current requirements on sustainability and process safety.
Scale-up
Scale or fail – but do it quickly! Our scale-up experience covers every stage of a process – we can take your ideas from the laboratory to kilogram-scale in a pilot plant and pave the path for commercial manufacturing. We cover a Technology Readiness Level (TRL) from 1 – 6 according to Horizon2020 definitions, or TRL 1 – 8 according to Vinnova.
Analysis
All fields, from pharmaceutics to consumer products, material chemistry, biofuels or bio-based chemicals share a great demand for chemical and physical analysis. We provide customized solutions for your specific analytical needs, ensuring highest quality for method development and validation, quality control, stability studies, problem solving and assessments.
Process safety
In any stage of process development, chemical process safety is of utmost importance. Acquiring relevant data requires expertise and equipment. For instance, we can support you on your journey towards a safe process with:
- General process safety evaluation and risk assessment
- Stability testing of compounds and mixtures under process-relevant conditions
- Reaction calorimetry and kinetics
- Material compatibility testing
Digitalisation
Many forms and amounts of data are accumulated during development work and we aim to collect as much data as possible for later analysis as required. We apply statistical modelling, from simple linear regressions to advanced machine learning techniques. Even artificial intelligence can be applied, e.g. in retrosynthetic analysis.
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