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Preclinical inhalation studies for evaluation of toxicity and efficacy

Are you running a project for new inhalation drugs or studying airborne pollutants? We offer complete solutions with high quality and versatile expertise in inhalation exposure so that you as a customer will receive the best service. We perform studies on rats and mice and are GLP compliant for toxicological studies.

We offer

For substances that are to be administered via inhalation:

  • Pharmacokinetic (PK) studies
  • Regulatory general toxicology studies, up to 6 months under GLP
  • Efficacy studies, such as inflammation models

Our systems

Inhalation tower

The exposure system enables the nebulization of liquids or the administration of dry powder aerosols. This can be performed in unanaesthetised animals, up to 60 animals per tower simultaneously, in four separate towers.

The exposure takes place via the nose, in a so-called "nose-only" administration, where the animals are allowed to inhale the aerosol for a defined period of time.

PreciseInhale®

The PreciseInhale® system can be used to administer substances either to intratracheally intubated animals under anesthesia, or to unanaesthetised or sedated animals by nose-only. The exposure system enables use of both nebulization of liquids or dry powder aerosols of test substances.

Our analyses

In accordance with guidelines, eg OECD TG412, we perform:

  • Aerodynamic characterization of substances (MMAD; mass median aerodynamic diameter, GSD; geometric standard deviation)
  • Chemical analysis for calculation of inhalation dose, bioanalysis
  • Bronchoalveolar lavage (BAL) for analysis of cells, cytokines and proteins
  • Macroscopic and microscopic pathology
Matilda Bäckberg

Contact person

Matilda Bäckberg

Enhetschef

Read more about Matilda

Contact Matilda
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