Pharmaceutical manufacturing without chlorinated solvents

The process step, which has proven problematic, is crucial for controlling the level of contaminants in the final product and the process yield has a significant effect on the amount of chemicals and solvents required in the preceding manufacturing steps.

Two new methods have been developed that avoid the use of large amounts of dichloromethane, which is both hazardous to health and a burden on the environment. One of the methods shortens the process by one step, making the process even more cost-effective and less environmentally damaging. The project has provided increased knowledge about how critical impurities are formed. The project objectives have been achieved and will form an important basis for continued process development.