Breakfast seminar: What impact can whole body imaging have on your preclinical research?

A whole-body monitoring system with bioluminescence camera for in vivo, ex vivo and in vitro applications, which is expected to support drug development in preclinical environments, has been installed in one of the RISE laboratories in Södertälje. 

– With this camera, we can capture the location and the distribution of tumors and measure the effectiveness of treatment in live animals, says Evelina Lindmark. We are working sustainably and saving the use of surplus animals, time and money, by following functional and anatomical changes in disease models over time in the same animals.  

During the past year, RISE has used the camera in collaboration with the Swedish biotech company Anocca. Anocca's business idea is to establish a unique technology platform for analysis of T-cell biology to unlock the therapeutic potential of T-cell immunity. 

So far, the camera has been used in in vivo experiments. Together with Anocca, RISE has developed a  work process where Anocca provides their tailored cell lines and RISE performs the in vivo phase of the study by monitoring tumor growth with the use of the bioluminescence camera, while Anocca takes care of and performs ex-vivo analyses. The results are put together and evaluated during joint meetings, in close collaboration between RISE’s and Anocca’s researchers. 

– We adapt our services to each individual partner, says Matilda Bäckberg. In this case, Anocca discussed their needs with us. A request of support in development of animal model which included a camera system was proposed. RISE believed that our facilities, animal research experience, and drug development knowledge were a great fit for their requirements. A camera was placed on our premises at RISE and our staff was trained in the technology. Now we carry out studies for Anocca on an ongoing basis, but the collaboration also includes optimizing the disease model we work with. This requires a wide range of skills and experience. 

During the seminar, we get to listen to Evelina Lindmark, researcher and study director for in vivo studies at RISE, Hugh Salter, CSO Anocca, and Hannes Uchtenhagen, Translational Sciences Lead at Anocca, and Matilda Bäckberg, project manager for the Pharma Office and director for RISE laboratory animal operations. The seminar is moderated by Cecilia Hyrén, research- and business developer at RISE. 

Registration 

The seminar is hosted by Pharma Office at RISE and held in English and broadcasted via Teams. Please register here.