FORMAMP - Innovative Nanoformulation of Antimicrobial Peptides

Aim and goal

The long-term objective of the FORMAMP project is to significantly change the treatment strategies for infectious diseases and to reduce the evolution of multi-resistant bacteria.

Challenge

Antimicrobial resistance

Solution

The specific aims of the project were to develop new and innovative formulation strategies for local administration, based on the combination of nanotechnology-based delivery systems and antimicrobial peptides, for the treatment of infectious diseases caused by bacteria such as Pseudomonas aeruginosa, MRSA (Methicillin-resistant Staphylococcus aureus), and MTB (Mycobacterium tuberculosis). Clinical indications that have been addressed include skin and soft tissue infections, infections in burn wounds, and infections in the lung such as cystic fibrosis and tuberculosis. A number of these indications are associated with the formation of multispecies biofilms, drastically impairing the function of available treatments. An important objective of the FORMAMP project was therefore to develop treatment strategies that also takes into account the problems associated with biofilms for clinical indications where this is of importance.

Effect

Reduce the drastic increase of resistant bacteria