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Master Thesis - Process properties influencing the foaming ability during vacuous foam drying


As it stands, freeze drying is currently the “gold standard” within development of dry protein formulations. However, limitations include its high energy consumption and often very long and complex process conditions, and consequently contribute a very high cost of operations. Thus, the pharmaceutical companies have requested a search for alternative drying technologies, for protein formulations. Within the research centre NextBioForm, we aim to explore alternative drying technologies for protein drugs to be utilized as dry formulations. Within the project, one of chosen techniques of interest is vacuous foam drying, which utilizes evaporative drying by moderate reduction of pressure, preferably at temperatures near room temperature. Vacuous foam drying can present milder drying conditions for biologics contributing to less impact on biological activity and stability.

Vacuous foam drying can be divided into two sections, a primary drying and a secondary drying. The primary drying is responsible for creating a solid foam whilst the secondary drying dries trapped residual solvent from the solid foam by diffusion and desorption. Since there are several factors influencing the vacuous foam drying much is still in an explorative stage. Hence, mapping of process conditions influencing the foaming ability and final quality of the dry foam will be of central importance of this master thesis project. The work will demand structured investigations linked to design of experiments and statistical analysis to demonstrate validity of process factors affecting the foaming properties. In this project we will use a protein as the biological drug compound.

Map the importance of selected process parameters in vacuum foam drying. Study the influence of process parameters on product quality in terms of solid-state properties and preserved biological activity. A design of experiments approach will be used.

During the project several important methods will be utilized e.g., vacuous foam drying, rheology measurements.

Master’s level studies in chemical engineering, biotechnology, or pharmaceutics with an interest in process design, experimental design, and biological materials.

RISE Research Institutes of Sweden, Stockholm (KTH Campus location).

Welcome with your application
Last day for applications is set at 9th of December, 2022 and applications are processed continuously. If you are want to know more, please contact: Daniel Osanlóo, PhD Student, daniel.osanloo@ri.se or Anna Fureby, Senior Researcher, anna.fureby@ri.se. Note that all applications for this position must go through our recruitment system Varbi. We do not accept applications by email.

Our union representatives are Lazaros Tsantaridis, SACO, 010 516 62 21 and Bertil Svensson, Unionen, 010-516 53 56.

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Student - examensarbete/praktik


Daniel Osanlóo



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