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Proteins are increasingly used as therapeutic agents for a wide variety of diseases. Although excellent therapeutics, proteins are sensitive biomacromolecules and the stability is critical for successful use. Thus, the formulation of therapeutic proteins in solution is a key to develop successful products.
This 1-day online course provides a straightforward introduction to the principles of formulation of proteins in solution. The course will give an introduction to parenteral protein delivery, key issues regarding physical and chemical stability of proteins in solution, and key excipients used in formulation of protein solutions. The application of the principles of formulation will be discussed in two case studies.
This course provides an introduction to the fundamental and practical aspects of formulations for proteins in solution.
The day is also the starting point for a 3 credit PhD course in formulation of proteins. The PhD course comprises 2 days of lectures, participation in 3 journal club discussions and an experimental session in the laboratory of your home institution.
The course is intended for industrialists, researchers and PhD students with an interest in proteins in solution with application to pharmaceutical science. The course is primarily a course for beginners in the field of protein formulation.
Prof Marie Wahlgren, Pharmaceutical Technology, Dept of Food science, technology and nutrition, Lund University. Marie is professor in pharmaceutical technology with a long experience both industrial and academic in the field of pharmaceutical formulations and surface colloid chemistry of proteins.
Adj. Prof Stefan Ulvenlund, Enza Biotech AB. Stefan is professor in formulation technology at Lund University, and CSO of Enza Biotech.
Dr Helen Sjögren, Principal scientist, Ferring Pharmaceuticals A/S. Helen has PhD in physical chemistry (LU). She has >15 years’ experience of parenteral drug formulations of proteins.
9:15-9:45 An introduction pharmaceutical proteins
9:50–10:20 Introduction to parenteral protein delivery
10:30-10:45 Quality demands on proteins drug products
10:50-11:20 Chemical pathways of protein degradation
11:30-12:00 Physical stability of proteins
Parenteral protein solutions:
13:00-13:20 Buffers and pH
14:05-14:35 Stabilisers, sugars, salts, amino acids etc.
14:40-14.50 Antioxidants and chelating agents
15:30-15:45 Novel formulation concepts
15:45-16:10 Case study: Insulin
16 :15-16:45 Case study: Gonadotropins
20 jan 2021, 09:15 - 16:45
Meeting link will be sent to registered participants
4 300 SEK excluding VAT
PhD students: no fee
NextBioForm partner organisations: no fee
Other participants: 4 300 SEK
18 jan 2021
The documentation of the course will be on a Canvas page containing slides from the presentations, in some cases recorded videos of the presentations as well as some literature and literature lists.
Cancellation up to 7 Days before the event 100% refund, cancellation 3 days before the event 50% refund. No refund if you cancel later than 3 days before the event. After informing the organizers a colleague can take your place if you cannot participate.Registration